Laura Rubio

Investigadora a Tiempo Completo

Correo electrónico: l.rubio@ce.pucmm.edu.do

Oficina: Escuela de Ciencias Naturales y Exactas, junto al laboratorio de NanoBiología, Pontificia Universidad Católica Madre y Maestra, Campus de Santiago de los Caballeros.

Researchgate

  • Doctora en Genética.
  • Maestría en Genética Avanzada.
  • Licenciatura en Biotecnología.

  • Deloid G., Sigh Sohal I., Rubio L., McClemments D., Demokritou P. Reducing Intestinal Digestion and Absorption of Fat Using a Nature-Derived Biopolymer: Interference of Triglyceride Hydrolysis by Nanocellulose. ACS Nano. 2018 24;12:6469-79.
  • Rubio L., Bach J., Marcos R., Hernández A. Synergistic role of nanoceria on the ability of tobacco-smoke to induce carcinogenic hallmarks in lung epithelial cells. Nanomedicine. 2017 12:2623-35.
  • DeLoid G.M., Wang Y., Kapronezai K., Rubio L., Zhang R., Pyrgiotakis G., Konduru N.V., Ericsson M., White J.C., De La Torre-Roche R., Xiao H., McClements D.J., Demokritou P. An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials. Part Fibre Toxicol. 2017 13;14 (1):40.
  • Sierra M.I., Rubio L., Bayón G.F., Cobo I., Menendez P., Morales P., Mangas C., Urdinguio R.G., Lopez V., Valdes A., Vales G., Marcos R., Torrecillas R., Fernández A.F., Fraga M.F. DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes. Nanotoxicology. 2017, 13:1-14.
  • Phuyal S., Kasem M., Rubio L., Karlsson H.L., Marcos R., Skaug V., Zienolddiny S. Effects on human bronchial epithelial cells following low-dose chronic exposure to nanomaterials: A 6-month transformation study. Toxicol In Vitro. 2017, 44:230-240.
  • Rubio L., Vila L., Annangi B., García-Rodríguez A., Marcos R., Hernández A. Frozen dispersions of nanomaterials are a useful operational procedure in nanotoxicology. Nanotoxicology. 2016, DOI: 10.1080/17435390.2016.1262918.
  • Carmona E., Inostroza-Blancheteau I., Rubio L., Marcos R. Genotoxic and oxidative stress potential of nanosized and bulk zinc oxide in Drosophila melanogaster. Toxicology and industrial health. 2016, 32(12):1987-2001.
  • Collins A.R., Annangi B., Rubio L., Marcos R., Dorn M., Merker C., Estrela-Lopis I., Cimpan M.R., Ibrahim M., Cimpan E., Ostermann M., Sauter A.,Yamani N.E., Shaposhnikov S., Chevillard S., Paget V., Grall R., Delic J., de-Cerio F.G., Suarez-Merino B., Fessard V., Hogeveen K.N., Fjellsbø L.M., Pran E.R., Brzicova T., Topinka J., Silva M.J., Leite P.E., Ribeiro A.R., Granjeiro J.M., Grafström R., Prina-Mello A., Dusinska M. High throughput toxicity screening and intracellular detection of nanomaterial. Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology. 2016, DOI: 10.1002/wnan.1413.
  • Rubio L., El-Yamani N., Dusinska M., Marcos R. Multi-walled carbon nanotubes (NM401) induce ROS and HPRT mutations in Chinese hamster lung fibroblast cells. Enviromental Research. 2016, 146:185-190.
  • Vales G., Rubio L., Marcos R. Genotoxic and cell-transformation effects of multi-walled carbon nanotubes (MWCNT) following in vitro long-term exposures. Journal of Hazardous Materials. 2015, 306:193-202.
  • Carmona E.R., Inostroza-Blancheteau C., Obando V., Rubio L., Marcos R. Genotoxicity of copper oxide nanoparticles in Drosophila melanogaster. Mutation Research. Genetic Toxicology and Environmental Mutagenesis. 2015, 791:1-11.
  • Annangi B., Rubio L., Alaraby M., Bach J., Marcos R., Hernández A. Acute and long-term in vitro effects of zinc oxide nanoparticles. Archives of Toxicology. 2015, DOI 10.1007/s00204-015-1613-7.
  • Rubio L., Annangi B., Vila L., Hernández A., Marcos R. Antioxidant and antigenotoxic effects of cerium oxide nanoparticles in BEAS-2B. Archives of Toxicology. 2015, 89:1-10.
  • Annangi B., Bach J., Vales G., Rubio L., Marcos R., Hernández A. Long-term exposures to low doses of cobalt nanoparticles induce cell-transformation enhanced by oxidative damage. Nanotoxicology. 2015, 9:138-147.
  • Vales G., Rubio L., Marcos R. Long-term exposures to low doses of titanium dioxide nanoparticles induce cell-transformation, but not genotoxic damage in BEAS-2B cells. Nanotoxicology. 2015, 9:568-578.
  • Alaraby M., Hernández A., Annangi B., Demir E., Bach J., Rubio L., Creus A., Marcos R. Drosophila as In Vivo Model to Determine the Potential Harmful Effects of Nanomaterials. Studies with Cerium Oxide. Nanotoxicology. 2015, 9:749-59.
  • Bedoya L., Martinez F., Rubio L., Daros JA. Simultaneous equimolar expression of multiple proteins in plants from a disarmed potyvirus vector. Journal of Biotechnology, 2010; 150 (2):268-275.

Capítulos de Libros

  • Rubio L. and Marcos R. Cerium chemical properties, applications and environmental impact. Chapter 4 Biological Effects Associated with Nanoceria Exposure. Nova Science Publishers Inc. New York. ISBN: 978-1-53612-433-0.

Modalidad póster

  • Rubio L., Bach J., Marcos R., Hernández A., 2016. Cerium Oxide nanoparticles (CeNPs) moderately enhance the cancer features induced by Cigarette smoke condensate (CSC) in human epithelial lung cells. 8th International Nanotoxicology Congress, NANOTOX 2016 (Boston, USA)
  • Rubio L., El-Yamani N., Dusinska M., Marcos R. Multi-walled carbon nanotubes (NM401) induce ROS and HPRT mutations in Chinese hamster lung fibroblast cells. QualityNano Conference and Training Workshop (Crete, Greece).
  • Vales G., Rubio L., Vela L., Creus A., Marcos R. 2012. DNA damage induced by silver nanoparticles in three different human cell lines (BEAS-2B, CACO-2 AND TK6). 1st Workshop on Nanomedicine UAB-CEI (Barcelona, Spain).
  • Annangi B., Bach J., Vales G., Rubio L., Marcos R., Hernández A. 2014. Long-term exposures to low doses of cobalt nanoparticles induce cell-transformation enhanced by oxidative damage. NanoBio&Med2014 International Conference (Barcelona, Spain).

Modalidad Oral

  • Rubio L., Bach J., Marcos R., Hernández A., 2018. Nanopartículas de óxido de Cerio (CeNPs) como potenciador moderado de las características tumorales inducidas por el condensado de humo de Tabaco (CSC) en células epiteliales de pulmón. XVIII Congreso en investigaciones científicas 2018 (Santo Domingo, República Dominicana)
  • Rubio L., Bach J., Marcos R., Hernández A., 2016. Cerium Oxide nanoparticles (CeNPs) moderately enhance the cancer features induced by Cigarette smoke condensate (CSC) in human epithelial lung cells. 8th International Nanotoxicology Congress, NANOTOX 2016 (Boston, USA)
  • Rubio L., L. Vila, B. Annangi, A. Hernández, R. Marcos. Antioxidant properties of cerium oxide nanoparticles in BEAS-2B cells. Annual Meeting of the Spanish Society of Environmental Mutagenesis (SEMA), Pamplona, June 2014.

Áreas de Investigación

  • Nanotoxicología
  • Nanobiología
  • Nanomateriales

Proyectos de investigación en curso

  • “Efectos toxicológicos de los microplásticos y nanoplásticos en organismos superiores”.
  • “Conocer para proteger: evaluación del riesgo para la salud de los micro y nanoplásticos presentes en la cuenca del caribe”.
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